Aliphatic β-Nitroalcohols for Therapeutic Corneoscleral Cross-Linking
نویسندگان
چکیده
منابع مشابه
Aliphatic beta-nitroalcohols for therapeutic corneoscleral cross-linking: chemical mechanisms and higher order nitroalcohols.
PURPOSE The recent tissue cross-linking studies indicate that aliphatic beta-nitroalcohols (BNAs) may be useful as pharmacologic corneoscleral cross-linking agents. The present study was performed to identify the specific chemistry involved under physiologic conditions, with the intent of identifying more effective agents. METHODS The mechanism of chemical cross-linking at pH 7.4 and 37 degre...
متن کاملAliphatic b-Nitroalcohols for Therapeutic Corneoscleral Cross-Linking: Chemical Stability Studies Using H-NMR Spectroscopy
Recent studies suggest that aliphatic b-nitro alcohols may represent a useful class of compounds for use as in vivo therapeutic corneoscleral cross-linking agents with higher order nitroalcohols (HONAs) showing enhanced efficacy over the mono-nitroalcohols. The current study was undertaken in order to evaluate the chemical stability of these compounds during storage conditions. Two mono-nitroal...
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PURPOSE Corneal collagen cross-linking through UVA-riboflavin photochemistry (UVAR) has been shown to be an effective treatment for keratoconus and related keratectasias. In recent studies using sclera, the authors observed that short-chain aliphatic beta-nitro alcohols can cross-link collagenous tissue under physiologic conditions. Thus, this study was undertaken to evaluate these agents as po...
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Cross linking of high density polyethylene (HDPE) was first performed via high energy10 Mev electron beam (EB) irradiation. HDPE was also cross linked withDicumyle peroxide (DCP).The gel content of samples was determined by solvent extraction.Degree of cross linking was evaluated by hot set apparatus; as well .In order to clarify the effectof nature of cross linking, correlation of electrical p...
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purpose: to evaluate the efficacy of riboflavin administration and ultraviolet a (uva) cross-linking on advanced symptomatic bullous keratopathy (bk). methods: 10 patients with symptomatic pseudophakic bullous keratopathy (pbk) were included. slit-lamp examination, visual acuity, foreign body sensation (fbs) and corneal thickness as measured by pentacam, were performed before corneal cross-link...
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ژورنال
عنوان ژورنال: Cornea
سال: 2013
ISSN: 0277-3740
DOI: 10.1097/ico.0b013e31825646de